Allergy risk by sulfite: food manufacturer expands its recall to additional products

Allergy risk by sulfite: food manufacturer expands its recall to additional products

Callback for lemon juice concentrate expanded – also lime juice concentrate affected

The Gunz warenhandels GmbH has launched a few days ago Piacelli Citrilemon lemon juice concentrate because of the increased sulfite content. Now the recall has been expanded massively. Meanwhile, goods are to be associated with another MHD, as well as the lime juice concentrate in the sale facility.

Meanwhile, lime juice concentrate is called back

The Gunz warenhandels GmbH from Austria has started a few days ago, a recall for Piacelli Citrilemon lemon juice concentrate, because in a Batch of product that was sold in Germany, a higher sulfite content was found. Now the recall has been expanded. Meanwhile, goods are to be associated with another MHD, as well as the lime juice concentrate in the sale of sites.

Increased sulfite content was not declared

The Gunz warenhandels GmbH won’t return your calls only Piacelli Citrilemon lemon juice concentrate 200 ml (EAN: 9002859018800), but also Piacelli Citrilemon lemon juice concentrate 1 l (EAN: 9002859042744), Piacelli Citrigreen lime juice concentrate 200 ml (EAN: 9002859026270), as well as Piacelli Citrigreen lime juice concentrate 1 l (EAN: 9002859101533).

Of the recall, all of the above products are affected with the minimum shelf-life data, 14.07.2020 – 17.12.2020.

“In the case of the above-mentioned product, an increased sulfite was found to be-content, which is not declared on the label,” writes the company in a notice published on the Portal “lebensmittelwarnung.de” the German länder and of the Federal office for consumer protection.

The consumption of sulfite-containing foods can cause in some people to severe intolerance reactions.

The purchase price will be refunded

The recall applies to the entire Federal territory.

As the company explained, was taken “all the necessary measures to avoid such an incident for the future.”

Buyers will be asked, the affected product to the place of return. The purchase price will be refunded.

Health Complaints

Sulphites are the salts and esters of Sulfurous acid, H2SO3. They are approved for use in many foods as additives and are used as a preservative and as an anti-oxidant.

As the Bavarian state office for health and food safety (LGL) writes on his website, sulfite salts in food of the most people tolerate it well, there’s a body’s own enzyme (sulfite oxidase) facilitates rapid Oxidation to harmless sulfate.

For some people, the consumption of sulfite-containing foods, however, severe incompatibility reactions such as asthmatic reactions.

“This intolerance in particular, a part of the Asthma patients are affected,” reports the LGL.

“Furthermore, it may occur in people with a deficit in the Enzymes sulfite oxidase to health complaints,” according to the experts.

The symptoms of intolerance reactions to sulfite salts resemble those of allergic reactions. (ad)

My 600-Lb. Life's Justin McSwain Struggles to Fit into SUV: 'I Really Can't Believe This'

My 600-Lb. Life's Justin McSwain Struggles to Fit into SUV: 'I Really Can't Believe This'

For 27-year-old Justin McSwain, tasks as small as getting into a car are a daily struggle.

The Rock Hill, South Carolina resident is more than 600 lbs. — a weight he hit from overeating.

In an exclusive clip from Wednesday’s episode of My 600-Lb. Life, McSwain attempts to fit into a Jeep at a car rental facility.

“I’m a little bit worried right now because I’m not sure how big this vehicle is going to be,” he says, walking up to the SUV. “That’s it? This isn’t the car I requested.”

McSwain pushes the seat back as far as it will go and he tries to sit in the driver’s seat: “It’s tight,” he says. “It’s not going to work.”

“I really can’t believe this,” he says. “This is the last thing I need. I’m trying really hard not to spiral and have a panic attack but I’m beyond my limit at this point.”

  • RELATED: Over 600-Lb. Woman Struggles to Stand Up Because of Lymphedema Growths: It’s ‘Excruciating’

Growing up, McSwain’s stepmom had padlocked his food supply and berated him for eating her “out of house and home.” So when he attended college, he started eating as much as he wanted. In just four years, he gained nearly 400 lbs. and was diagnosed with agoraphobia — fear of places and situations that might cause panic, helplessness, or embarrassment.

RELATED VIDEO: Arnold Schwarzenegger’s Son Joseph Baena Shows Off His Muscles & Recreates His Dad’s Classic Pose

This week’s episode explores his journey in joining Dr. Now’s weight-loss program and how his father has become his main support system while he seeks recovery.

My 600-Lb. Life airs Wednesdays at 8/7c on TLC.

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The Amazing Thing Kate Middleton Is Doing to Help Families In Need

The Amazing Thing Kate Middleton Is Doing to Help Families In Need

Kate Middleton is more than “just another royal.” The Duchess of Cambridge has spent the last few years championing various causes, particularly those issues which impact our children and our mental health. And it seems the future queen is at it again: Kate Middleton just launched a new U.K. support line, one which is designed to assist families in need.

The FamilyLine service is a collaborative effort between Kate and Family Action, a nonprofit which aims to “transform lives by providing practical, emotional and financial support to those who are experiencing poverty, disadvantage and social isolation across the country.” And while Family Action has accomplished these goals for more than 150 years — through numerous outreach efforts, programs and services —  FamilyLine will be the organizations first “virtual” offering.

So how does FamilyLine work?

According to Family Action, the hotline will be open weekday evenings and weekend mornings to “support any family member struggling with any aspect of family life, such as parenting challenges, family conflict, relationship difficulties or mental health and wellbeing.” Calls, texts and emails will be answered quickly and confidentially and both short- and long-term support will be available free of charge.

This isn’t Kate’s first time working with Family Action. In November 2017, she visited the Hornsey Road Children’s Centre to discuss the many challenges parents face, including her and Prince William. The Duchess of Cambridge admitted that William didn’t know exactly what to do when he first became a father to Prince George — but really, what new parent does?

As for the hotline, if you live in the U.K. and find yourself in need of guidance, support or advice, be sure to check out this amazing service. Help is just a call (or message) away.

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Erasing memories associated with cocaine use reduces drug seeking behavior

Erasing memories associated with cocaine use reduces drug seeking behavior

Forty to 60 percent of all people treated for substance use disorders relapse, presenting a major challenge to treatment success. New research from the University of Pittsburgh School of Medicine shows that disrupting memories that associate environmental cues with drug use significantly reduces drug seeking behaviors in rats, opening a potential avenue for developing more effective therapies to prevent relapse.

Since Pavlov discovered classical conditioning in dogs in the 1890s, it has long been recognized that the brain associates specific cues with behaviors, like the smell of freshly brewed coffee making you want to drink a cup, or the sight of a snake inducing a heightened fear response. Breaking the links between cues and memories is a well-known strategy in treating phobias, addiction and PTSD.

But this method—commonly known as ‘exposure therapy’ – is not very effective at treating addiction. The reason? Context matters. While exposure therapy might have some effect in a controlled setting such as a doctor’s or therapist’s office, the moment a person suffering from addiction is faced with the cue in the outside world, the brain fires off the same neurons connected to drug-seeking behavior.

“While we’ve always known that the brain forms these cue-associated memories, the specific circuits have never been clearly identified,” said Mary Torregrossa, Ph.D., associate professor of psychiatry at Pitt’s School of Medicine and senior author of the study, published today in Cell Reports. “We’ve found a central piece in the cue-memory puzzle, and we also show that taking out that piece in a substance use scenario can help reverse relapse-like behaviors.”

In the study, the scientists used a rat model of cue-associated relapse. When rats pressed a lever, they received an infusion of cocaine, accompanied by a tone and a light. With training, the rats learned to associate the audiovisual cue with the cocaine high, and exhibited drug-seeking behavior analogous to craving, repeatedly pressing the lever.

The researchers also simulated exposure therapy in the rats, showing that repeatedly playing the tone and light without providing the cocaine infusion eventually reduced drug-seeking behavior. But much like in humans, exposure therapy in the rats did not work well if they were placed in a different environment.

Using electrical recordings from rat brain tissue, Torregrossa and her team first showed that connections between the medial geniculate nucleus—the brain’s switchboard for sound—and the lateral amygdala are important for forming memories that associate the cocaine high with external cues.

“It made sense to us because the amygdala is where emotional memories are formed,” said Matthew Rich, a graduate student in Torregrossa’s lab and the first author of the study. “It receives sensory input and associates that input with what we feel when the cues are presented to us.”

To show a causal connection between these cue-associated memories and drug-seeking behavior, the researchers used a technique known as optogenetics, where light pulses are used to control genetically modified cells, to control the neurons from the previous experiment. Rats that had the cocaine-cue memories optogenetically erased pressed the lever significantly fewer times when the light and tone cue were played.

Importantly, the reduced relapse behavior persisted even when the rats were placed in a different environment, suggesting that eliminating cue-associated memories overcomes the relapse-inducing effects of a new environment.

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How to develop personalised diabetes treatment

How to develop personalised diabetes treatment

Diabetes can lead to blindness, kidney failure, heart attack, stroke, lower limb amputation and premature death. It was the seventh leading cause of death in 2016, according to the World Health Organization. The Diabetes Atlas of the International Diabetes Federation (IDF) predicts that by 2045, some 629 million people (aged 20-79) will have diabetes if no action is taken. The IDF also notes that in high-income countries, about 87 percent to 91 percent of all people with diabetes are estimated to have type 2 diabetes, compared with 7 percent to 12 percent who are estimated to have type 1 diabetes. Considering the fact that type 2 diabetes is rising across all regions in the world and that the effectiveness of existing therapies varies significantly between individuals, scientists are increasingly focusing on targeted treatments.

The EU-funded RHAPSODY project set out to examine type 2 diabetes, and the partners believe it has the potential to revolutionise the way doctors deal with the condition. Quoted in a European Commission news item, vice project coordinator Leif Groop of Lund University in Sweden says RHAPSODY involves “individualising diabetes treatment.” He adds: “For too long, we have had the situation that one size fits all.”

Personalised medicine

RHAPSODY, together with the EU-funded BEAt-DKD project, among others, has split type 2 diabetes into five subgroups, according to the same news item. The research has drawn on the findings of a Swedish study known as ANDIS that was initiated by Groop. “The subgroups divide type 2 patients into those with severe autoimmune diabetes, those with severe insulin deficiency, those with severe insulin resistance, and those whose diabetes is mild and linked to obesity or age.”

Thanks to such classification, the risk of complications could be addressed properly and patients offered the correct treatment accordingly. “For example, while people with severe insulin deficiency are at high risk of developing eye problems, those with severe insulin resistance have a five-fold greater chance of contracting kidney disease compared to individuals in the other subgroups.”

RHAPSODY is also developing a computerised tool to personalise diabetes care. “Using a blood sample, the so-called clinical support system will be able to match a person with a subgroup and then suggest the best treatment plan. It will take the risk of complications into consideration, helping to ensure that everything is done to keep these in check.” Testing will start in Sweden and Finland by the end of 2018.

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China’s second gene-edited foetus is 12-14 weeks old: scientist

China’s second gene-edited foetus is 12-14 weeks old: scientist

The second woman carrying a gene-edited foetus in China is now 12 to 14 weeks into her pregnancy, according to a US physician in close contact with the researcher who claimed to have created the world’s first genetically-modified babies last year.

Chinese scientist He Jiankui shocked the scientific community after revealing that he had successfully altered the DNA of twin girls born in November to prevent them from contracting HIV.

State media reported on Monday that a preliminary investigation confirmed that a second woman became pregnant and that she will be put under medical observation, but no other details about her are known.

Professor He, who now faces a police investigation, had mentioned the potential second pregnancy at a human genome conference in Hong Kong in late November, but its status was unclear until now.

William Hurlbut, a physician and bioethicist at Stanford university in California who has known He for two years, told AFP it was “too early” at the time for the foetus to appear on an ultrasound.

Based on extensive conversations with He, Hurlbut said: “I get the impression the baby was fairly young when the conference happened. It could only be detected chemically, not clinically (at the time).

“So it could be no more than four to six weeks old (at the time), so now it could be about 12 to 14 weeks.”

Hurlbut said he had planned to visit He’s lab following the genome summit. They had seen each other several times over the past two years.

But after news of his experiment was published, He was placed “under protection of security people” and the two never saw each other in person, he said.

They exchanged emails and spoke on the phone every week after that, but Hurlbut last heard from He seven days ago.

He has been residing in an apartment at the Southern University of Science and Technology (SUSTech) in the city of Shenzhen, where his family has been allowed to visit him in the day time, Hurlbut said.

“He doesn’t sound like a person under terrible fear or stress.” said Hurlbut.

“He said he was free to go out on to the campus and walk around.”

But He could be facing legal trouble.

A probe by the Guangdong provincial government found that He had “forged ethical review papers” and “deliberately evaded supervision”, according to state-run Xinhua news agency.

He had “privately” organised a project team that included foreign staff, it said.

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Selena Gomez Broke Her Instagram Hiatus With These Seriously Cool Sneakers

Selena Gomez Broke Her Instagram Hiatus With These Seriously Cool Sneakers

Our girl Selena is back in a BIG way – on the ‘gram and in the style stakes.

After a four-month break, the 26-year-old made her return to social media last week to reflect on what was a challenging 2018 both physically and mentally. Less than 24-hours later she blessed our feeds again, this time to dish the deets on her latest collab with Puma. And woaaaaahhhh MAMA, we are definitely buying what she’s selling.

“Lots to look forward to in 2019,” she wrote. “I can’t wait to share the projects I’ve been working on with you. The first one is here: Cali 👟 BY @pumasportstyle.”

A quick gander at PUMA’s website will tell you that The Cali Sneakers are an update on one of the brand’s sell-out styles from the ‘80’s.

“The classic ‘80’s Puma California has been reimagined to create the Cali,” the product description reads. “Originally a laid-back training sneaker, the Cali has been given an edge with progressive rubber tooling whilst the upper remains true to the original.”

They also come in few different colour combos: black-on-black, black upper with a white sole and Sel’s personal fave, white upper with a black sole. And good news: they’re on sale RIGHT NOW, over at The Iconic (a pair will set you back just $112.)

Our advice? Run don’t walk. Coz if the feedback from her 114m fans are anything to go by, these babies won’t be in stock for long. You’ve officially been warned!

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Salad, soda and socioeconomic status: Mapping a social determinant of health in Seattle

Salad, soda and socioeconomic status: Mapping a social determinant of health in Seattle

Seattle residents who live in waterfront neighborhoods tend to have healthier diets compared to those who live along Interstate-5 and Aurora Avenue, according to new research on social disparities from the University of Washington School of Public Health. The study used local data to model food consumption patterns by city block. Weekly servings of salad and soda served as proxies for diet quality.

The dramatic geographic disparities between salad eaters and soda drinkers were driven by house prices, according to the study. The lowest property values were associated with less salad and more soda; the opposite was true of the highest property values, after adjusting for demographics.

This is the first study to model eating patterns and diet quality at the census-block level, the smallest geographic unit used by the U.S. Census Bureau. The paper, published Jan. 9 in the journal Social Science and Medicine — Population Health, provides a new area-based tool to identify communities most in need of interventions to increase fruit and vegetable consumption.

“Our dietary choices and health are determined to a very large extent by where we live,” said the study’s lead author, Adam Drewnowski, professor of epidemiology and director of the Nutritional Sciences Program and Center for Public Health Nutrition at the School. “In turn, where we live can be determined by education, incomes and access to both material and social resources. We need a closer look at the socioeconomic determinants of health.”

Researchers geo-localized dietary data of nearly 1,100 adult participants of the Seattle Obesity Study based on their home addresses, and linked them to residential property values obtained from the King County tax assessor. Information on age, gender and race/ethnicity as well as education and annual household income were gathered via telephone surveys. Participants were also asked how often they ate salad and/or drank soda. Healthy Eating Index scores, a measure of diet quality, were calculated for each participant. Scores range from 0 to 100 with higher scores indicating better diet quality.

People who ate more salad tended to have higher Healthy Eating Index scores associated with more healthy eating behaviors. People who drank more soda tended to have lower scores.

While the disparities of soda consumption by neighborhood were clear, there was no significant difference by age, income or education. However, researchers did find that Black and Hispanic residents reported more frequent soda consumption than White residents. Women tended to eat more salad than men, as did adults age 55 and older. Adults with some college education or more consumed salad more often every week than those with only a high school education or less. Also, people earning $50,000 or more ate more salad per week than those earning less than $50,000 annually. There was no significant difference in salad consumption by race or ethnicity.

“Salad and soda are the two hallmarks of a healthy versus an unhealthy diet,” Drewnowski said. “We now show that they tend to be consumed by different people with different education and incomes, living in different neighborhoods in Seattle.”

Researchers selected salad and soda because they were used as the proxy of diet quality in the Behavioral Risk Factors Surveillance Study. They are also frequent targets for obesity prevention policy intervention. A good example of this is Seattle’s so-called soda tax, which took effect in January 2018.

“Interventions towards promoting healthier diets tend to focus on taxing soda, which is perceived as too cheap, and reducing the price of fresh produce, which is perceived as too expensive,” Drewnowski said. “Initiatives to replace soda with salad come across the issue of socioeconomic status and income purchasing power, and those are very complex issues.”

As more states and municipalities seek to develop targeted interventions for better health, they will need place-based tools to identify high-risk or high-need communities, according to the study.

The Seattle Obesity Study was a population based study of 2,001 male and female residents of King County, Washington. The aim was to examine the role of access to foods in influencing dietary choices and, thereby, contributing to disparities in obesity. The study recently expanded to include Pierce and Yakima counties. Drewnowski and his team plan to conduct similar research in those regions.

“We look forward to seeing those results,” Drewnowski said. “Yakima has a large population of Hispanics and the closest supermarket is 20 miles away; not to mention obesity looks very different in Yakima than it does in Seattle.”

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Implantable device curbs seizures and improves cognition in epileptic rats

Implantable device curbs seizures and improves cognition in epileptic rats

A protein-secreting device implanted into the hippocampus of epileptic rats reduces seizures by 93 percent in three months, finds preclinical research published in JNeurosci. These results support ongoing development of this technology and its potential translation into a new treatment for epilepsy.

Motivated by an unmet need for effective and well-tolerated epilepsy therapies, Giovanna Paolone and colleagues of the University of Ferrara, Italy and of Gloriana Therapeutics, Inc. (Providence, RI) investigated the effects of the Gloriana targeted cellular delivery system for glial cell line-derived neurotrophic factor (GDNF)—a protein recent research suggests may help suppress epileptic activity.

In addition to quickly and progressively reducing seizures in male rats—by 75 percent within two weeks—the researchers found their device improved rats’ anxiety-like symptoms and their performance on an object recognition task, indicating improvement in cognition.

The treatment also corrected abnormalities in brain anatomy associated with epilepsy. These effects persisted even after the device was removed, indicating this approach may modify the disease progression.


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Genetic study reveals possible new routes to treating osteoarthritis

Genetic study reveals possible new routes to treating osteoarthritis

In the largest genetic study of osteoarthritis to date, scientists have uncovered 52 new genetic changes linked to the disease, which doubles the number of genetic regions associated with the disabling condition.

Scientists at the Wellcome Sanger Institute, GSK and their collaborators analysed the genomes of over 77,000 people with osteoarthritis. Their findings, published today in Nature Genetics, revealed new genes and biological pathways linked to osteoarthritis, which could help identify starting points for new medicines. Researchers also highlighted opportunities for existing medicines to be evaluated in osteoarthritis.

Almost ten million people in the UK suffer from osteoarthritis, a degenerative joint disease in which a person’s joints become damaged, stop moving freely and become painful. There is no disease-modifying treatment for osteoarthritis. The disease is managed with pain relief medications and often culminates in joint replacement surgery, which has variable outcomes.

Osteoarthritis is the most prevalent musculoskeletal disease and a leading cause of disability worldwide. In the UK, the disease indirectly costs the economy £14.8 billion each year.

To uncover the genetics underpinning osteoarthritis, scientists from the Sanger Institute, GSK and their collaborators analysed the whole genomes of over 77,000 people with osteoarthritis and over 370,000 healthy people using patient data from the UK Biobank resource and the arcOGEN study. The team studied many different types of osteoarthritis, including in knee and hip joints.

Professor Eleftheria Zeggini, previously from the Wellcome Sanger Institute and now based at Helmholtz Zentrum München in Germany, said: “Osteoarthritis is a very common, disabling disease with no cure. We have conducted the largest study of osteoarthritis to date, and found over 50 new genetic changes that increase the risk of developing osteoarthritis. This is a major step forward in developing treatments to help the millions of people suffering from the disease.”

In order to discover which genes cause osteoarthritis, the team incorporated additional functional genomic data and analysed gene activity by measuring gene expression down to the protein level. The team integrated genetic and proteomic data on tissue taken from patients undergoing joint replacement surgery. By incorporating many different data sets, scientists were able to identify which genes were likely to be causal for osteoarthritis.

Ten of the genes were highlighted as targets of existing drugs, which are either in clinical development or approved for use against osteoarthritis and other diseases. These include the drugs INVOSSA, which is registered for knee osteoarthritis, and LCL-161, a drug in clinical development for the treatment of breast cancer, leukaemia and myeloma. The team suggest that the ten drugs highlighted would be good candidates for testing in osteoarthritis.

Dr. Stephen Simpson, Director of Research at Versus Arthritis, who supported the arcOGEN study, said: “Osteoarthritis affects over 8.5 million people across the UK. We know that the condition impacts people in different ways, meaning the treatment that works for one person doesn’t always work for someone else.

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